Approaches to detecting immunotoxic effects of environmental contaminants in humans.

Approaches to detecting immunotoxic effects of environmental contaminants in humans.

Experimental animal studies indicate that environmental contaminants can have adverse effects on several organs and tissues of the immune system. Such effects are known to lead to increased host susceptibility to microbial infections and to compromised immunosurveillance mechanisms normally instrumental in the elimination of neoplastic cells and the prevention of autoimmune diseases. Evaluation...

Assessment of immunotoxic effects in humans.

The immunotoxic effects of chemicals are varied and markedly different depending on the underlying pathogenesis, namely, direct immunotoxicity (including immunosuppression, immunodepression, and immunostimulation), hypersensitivity, and autoimmunity. A large number of immunological endpoints and functional assays have been proposed for use as biomarkers of immunotoxicity, but they often lack se...

Approaches to Monitoring Organic Environmental Contaminants in Food

Trace quantities of potentially toxic organic compounds are frequently found in the environment. These compounds sometimes possess properties that may have teratogenic, mutagenic, and even carcinogenic effects on humans and animals. Some of the compounds, such as pesticides, have been intentionally released into the environment (1), while others have found their way into the environment by acci...

Overview: Human Health Effects of Environmental Contaminants

environmental effects of gol-e-gohar iron ore mine on groundwater of the area

gol-e-gohar iron ore mine of sirjan in southern part of iran is a large open pit that operates below the groundwater table and during mining operation, dewatering is required to prevent operation processes from flooding. current operation is going on by digging wells in or out of the pit and pumping to prevent flooding. as a result of the former dewatering operation a vast deep cone of depressi...